rs2291766
Variant in the TJP1 gene (Tight Junction Protein 1)
rs2291766 is a single nucleotide polymorphism (SNP) in the TJP1 gene, involved in tight junction. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2291766 variant?
rs2291766 is a SNP (single nucleotide polymorphism) in the TJP1 (Tight Junction Protein 1) gene. It belongs to the Gut Barrier category and is part of the Gut-Brain Axis biological cluster. TJP1 (ZO-1) is a scaffold protein at tight junctions that links transmembrane claudins and occludin to the actin cytoskeleton. It is essential for junction assembly and barrier maintenance.
Biological role and pathway
This variant sits within the TJP1 gene, which is involved in the tight junction pathway. Genes within the Gut-Brain Axis cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2291766 and Long COVID / ME-CFS research
Zonulin and ZO-1 are biomarkers of intestinal permeability elevated in COVID-19. TJP1 variants affecting tight junction scaffold function may predispose to leaky gut and microbial translocation contributing to Long COVID systemic inflammation.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: TJP1
rs2291766 is one of 3 known variants in the TJP1 gene. To understand the full biological context of this variant, explore the parent gene page.
View TJP1 gene page →Conditions studied in relation to rs2291766
Research into TJP1 variants including rs2291766 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include TJP1 and the rs2291766 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the TJP1 gene
The following variants in TJP1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2291766 variant in the TJP1 gene?
rs2291766 is a single nucleotide polymorphism (SNP) located in the TJP1 (Tight Junction Protein 1) gene, which is involved in tight junction. TJP1 (ZO-1) is a scaffold protein at tight junctions that links transmembrane claudins and occludin to the actin cytoskeleton. It is essential for junction assembly and barrier maintenance.
How may the rs2291766 variant relate to Long COVID or ME/CFS?
Zonulin and ZO-1 are biomarkers of intestinal permeability elevated in COVID-19. TJP1 variants affecting tight junction scaffold function may predispose to leaky gut and microbial translocation contributing to Long COVID systemic inflammation.
Can a consumer DNA test detect the rs2291766 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2291766 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for TJP1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 29289576
- [2]Gut
- [3]American Journal of Physiology-Gastrointestinal and Liver Physiology