rs4696480
Variant in the TLR2 gene (Toll-Like Receptor 2)
rs4696480 is a single nucleotide polymorphism (SNP) in the TLR2 gene, involved in pattern recognition. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs4696480 variant?
rs4696480 is a SNP (single nucleotide polymorphism) in the TLR2 (Toll-Like Receptor 2) gene. It belongs to the Innate Immunity category and is part of the Innate Immunity & Interferons biological cluster. TLR2 recognizes bacterial lipoproteins, peptidoglycan, and fungal beta-glucans in heterodimers with TLR1 or TLR6. It activates NF-κB through MyD88 and shapes innate-adaptive immune transitions.
Biological role and pathway
This variant sits within the TLR2 gene, which is involved in the pattern recognition pathway. Genes within the Innate Immunity & Interferons cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs4696480 and Long COVID / ME-CFS research
TLR2 senses viral proteins including SARS-CoV-2 envelope protein, contributing to COVID-19 cytokine storm. TLR2 polymorphisms may affect COVID-19 severity and alter the innate immune tone underlying persistent Long COVID inflammation.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: TLR2
rs4696480 is one of 3 known variants in the TLR2 gene. To understand the full biological context of this variant, explore the parent gene page.
View TLR2 gene page →Conditions studied in relation to rs4696480
Research into TLR2 variants including rs4696480 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include TLR2 and the rs4696480 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the TLR2 gene
The following variants in TLR2 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs4696480 variant in the TLR2 gene?
rs4696480 is a single nucleotide polymorphism (SNP) located in the TLR2 (Toll-Like Receptor 2) gene, which is involved in pattern recognition. TLR2 recognizes bacterial lipoproteins, peptidoglycan, and fungal beta-glucans in heterodimers with TLR1 or TLR6. It activates NF-κB through MyD88 and shapes innate-adaptive immune transitions.
How may the rs4696480 variant relate to Long COVID or ME/CFS?
TLR2 senses viral proteins including SARS-CoV-2 envelope protein, contributing to COVID-19 cytokine storm. TLR2 polymorphisms may affect COVID-19 severity and alter the innate immune tone underlying persistent Long COVID inflammation.
Can a consumer DNA test detect the rs4696480 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs4696480 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for TLR2 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33009579
- [2]Nature Immunology
- [3]PLoS Pathogens