rs3775291

What is the rs3775291 variant?

rs3775291 is a SNP (single nucleotide polymorphism) in the TLR3 (Toll-Like Receptor 3) gene. It belongs to the Innate Immunity category and is part of the Viral Defense & Interferon Response biological cluster. TLR3 encodes a pattern recognition receptor that detects double-stranded RNA, triggering innate immune responses to viral infection.

Biological role and pathway

This variant sits within the TLR3 gene, which is involved in the pattern recognition receptor signaling pathway. Genes within the Viral Defense & Interferon Response cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: TLR3

rs3775291 is one of 1 known variant in the TLR3 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs3775291

Research into TLR3 variants including rs3775291 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include TLR3 and the rs3775291 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions