rs111200466

What is the rs111200466 variant?

rs111200466 is a SNP (single nucleotide polymorphism) in the TLR5 (Toll-Like Receptor 5) gene. It belongs to the Innate Immunity category and is part of the Viral Defense & Interferon Response biological cluster. TLR5 recognizes bacterial flagellin and is involved in mucosal and systemic innate immune responses.

Biological role and pathway

This variant sits within the TLR5 gene, which is involved in the pattern recognition receptor signaling pathway. Genes within the Viral Defense & Interferon Response cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: TLR5

rs111200466 is one of 1 known variant in the TLR5 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs111200466

Research into TLR5 variants including rs111200466 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include TLR5 and the rs111200466 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions