rs5743836
Variant in the TLR9 gene (Toll-Like Receptor 9)
rs5743836 is a single nucleotide polymorphism (SNP) in the TLR9 gene, involved in pattern recognition. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs5743836 variant?
rs5743836 is a SNP (single nucleotide polymorphism) in the TLR9 (Toll-Like Receptor 9) gene. It belongs to the Innate Immunity category and is part of the Innate Immunity & Interferons biological cluster. TLR9 recognizes unmethylated CpG DNA motifs characteristic of bacterial and viral genomes in endosomes. It is highly expressed in plasmacytoid dendritic cells and drives type I interferon production and B cell activation.
Biological role and pathway
This variant sits within the TLR9 gene, which is involved in the pattern recognition pathway. Genes within the Innate Immunity & Interferons cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs5743836 and Long COVID / ME-CFS research
TLR9 activation by mitochondrial DNA released during cell stress contributes to sterile inflammation. In Long COVID, circulating mitochondrial DNA may perpetuate TLR9-driven interferon signaling and B cell hyperactivation underlying autoantibody production.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: TLR9
rs5743836 is one of 3 known variants in the TLR9 gene. To understand the full biological context of this variant, explore the parent gene page.
View TLR9 gene page →Conditions studied in relation to rs5743836
Research into TLR9 variants including rs5743836 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include TLR9 and the rs5743836 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the TLR9 gene
The following variants in TLR9 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs5743836 variant in the TLR9 gene?
rs5743836 is a single nucleotide polymorphism (SNP) located in the TLR9 (Toll-Like Receptor 9) gene, which is involved in pattern recognition. TLR9 recognizes unmethylated CpG DNA motifs characteristic of bacterial and viral genomes in endosomes. It is highly expressed in plasmacytoid dendritic cells and drives type I interferon production and B cell activation.
How may the rs5743836 variant relate to Long COVID or ME/CFS?
TLR9 activation by mitochondrial DNA released during cell stress contributes to sterile inflammation. In Long COVID, circulating mitochondrial DNA may perpetuate TLR9-driven interferon signaling and B cell hyperactivation underlying autoantibody production.
Can a consumer DNA test detect the rs5743836 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs5743836 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for TLR9 and its variants. This is not an exhaustive literature review.
- [1]PMID: 30837127
- [2]Nature Reviews Immunology
- [3]Immunity