rs1800629

What is the rs1800629 variant?

rs1800629 is a SNP (single nucleotide polymorphism) in the TNF (Tumor Necrosis Factor) gene. It belongs to the Immune Signaling category and is part of the Immune System & Inflammation biological cluster. TNF encodes tumor necrosis factor, a central mediator of systemic inflammation, apoptosis, and immune cell activation.

Biological role and pathway

This variant sits within the TNF gene, which is involved in the cytokine signaling pathway. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: TNF

rs1800629 is one of 1 known variant in the TNF gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs1800629

Research into TNF variants including rs1800629 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include TNF and the rs1800629 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions