rs1131580

What is the rs1131580 variant?

rs1131580 is a SNP (single nucleotide polymorphism) in the TNFSF10 (TNF Superfamily Member 10 (TRAIL)) gene. It belongs to the Immune Signaling category and is part of the Cytokines & Immune Signaling biological cluster. TNFSF10 encodes TRAIL, a TNF superfamily member that selectively induces apoptosis in stressed and virally infected cells.

Biological role and pathway

This variant sits within the TNFSF10 gene, which is involved in the apoptosis and immune surveillance pathway. Genes within the Cytokines & Immune Signaling cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: TNFSF10

rs1131580 is one of 1 known variant in the TNFSF10 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs1131580

Research into TNFSF10 variants including rs1131580 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include TNFSF10 and the rs1131580 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions