rs1042522

What is the rs1042522 variant?

rs1042522 is a SNP (single nucleotide polymorphism) in the TP53 (Tumor Protein P53) gene. It belongs to the Genome Stability category and is part of the Oxidative Stress biological cluster. TP53 encodes p53, the 'guardian of the genome', a transcription factor activated by various stresses to trigger cell cycle arrest, DNA repair, or apoptosis.

Biological role and pathway

This variant sits within the TP53 gene, which is involved in the cellular stress response / apoptosis pathway. Genes within the Oxidative Stress cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: TP53

rs1042522 is one of 2 known variants in the TP53 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs1042522

Research into TP53 variants including rs1042522 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include TP53 and the rs1042522 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the TP53 gene

The following variants in TP53 are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions