rs11675434
Variant in the TPO gene (Thyroid Peroxidase)
rs11675434 is a single nucleotide polymorphism (SNP) in the TPO gene, involved in thyroid hormone synthesis. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs11675434 variant?
rs11675434 is a SNP (single nucleotide polymorphism) in the TPO (Thyroid Peroxidase) gene. It belongs to the Hormonal category and is part of the Hormonal Regulation biological cluster. TPO encodes thyroid peroxidase, an enzyme essential for thyroid hormone biosynthesis and the major autoantigen in Hashimoto's thyroiditis.
Biological role and pathway
This variant sits within the TPO gene, which is involved in the thyroid hormone synthesis pathway. Genes within the Hormonal Regulation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs11675434 and Long COVID / ME-CFS research
Thyroid dysfunction is prevalent after COVID-19; TPO variants and autoantibodies may contribute to post-COVID hypothyroidism and fatigue.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: TPO
rs11675434 is one of 2 known variants in the TPO gene. To understand the full biological context of this variant, explore the parent gene page.
View TPO gene page →Conditions studied in relation to rs11675434
Research into TPO variants including rs11675434 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include TPO and the rs11675434 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the TPO gene
The following variants in TPO are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs11675434 variant in the TPO gene?
rs11675434 is a single nucleotide polymorphism (SNP) located in the TPO (Thyroid Peroxidase) gene, which is involved in thyroid hormone synthesis. TPO encodes thyroid peroxidase, an enzyme essential for thyroid hormone biosynthesis and the major autoantigen in Hashimoto's thyroiditis.
How may the rs11675434 variant relate to Long COVID or ME/CFS?
Thyroid dysfunction is prevalent after COVID-19; TPO variants and autoantibodies may contribute to post-COVID hypothyroidism and fatigue.
Can a consumer DNA test detect the rs11675434 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs11675434 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for TPO and its variants. This is not an exhaustive literature review.
- [1]PMID: 34316049
- [2]Nature Genetics
- [3]Journal of Clinical Investigation