rs2229340

What is the rs2229340 variant?

rs2229340 is a SNP (single nucleotide polymorphism) in the TRAC (T Cell Receptor Alpha Constant) gene. It belongs to the Immune Signaling category and is part of the HLA & Immune Presentation biological cluster. TRAC encodes the constant region of the TCR alpha chain, essential for TCR complex assembly and T cell antigen recognition.

Biological role and pathway

This variant sits within the TRAC gene, which is involved in the T cell receptor signaling pathway. Genes within the HLA & Immune Presentation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: TRAC

rs2229340 is one of 1 known variant in the TRAC gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs2229340

Research into TRAC variants including rs2229340 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include TRAC and the rs2229340 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions