rs251457
Variant in the TRAF6 gene (TNF Receptor Associated Factor 6)
rs251457 is a single nucleotide polymorphism (SNP) in the TRAF6 gene, involved in TLR and IL-1R NF-kB signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs251457 variant?
rs251457 is a SNP (single nucleotide polymorphism) in the TRAF6 (TNF Receptor Associated Factor 6) gene. It belongs to the Innate Immunity category and is part of the Innate Immunity & Pattern Recognition biological cluster. TRAF6 encodes an E3 ubiquitin ligase that activates NF-kB and MAPK signaling downstream of TLRs and the IL-1 receptor.
Biological role and pathway
This variant sits within the TRAF6 gene, which is involved in the TLR and IL-1R NF-kB signaling pathway. Genes within the Innate Immunity & Pattern Recognition cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs251457 and Long COVID / ME-CFS research
TRAF6-mediated innate immune activation is central to the inflammatory cytokine cascade that may be dysregulated in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: TRAF6
rs251457 is one of 2 known variants in the TRAF6 gene. To understand the full biological context of this variant, explore the parent gene page.
View TRAF6 gene page →Conditions studied in relation to rs251457
Research into TRAF6 variants including rs251457 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include TRAF6 and the rs251457 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the TRAF6 gene
The following variants in TRAF6 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs251457 variant in the TRAF6 gene?
rs251457 is a single nucleotide polymorphism (SNP) located in the TRAF6 (TNF Receptor Associated Factor 6) gene, which is involved in TLR and IL-1R NF-kB signaling. TRAF6 encodes an E3 ubiquitin ligase that activates NF-kB and MAPK signaling downstream of TLRs and the IL-1 receptor.
How may the rs251457 variant relate to Long COVID or ME/CFS?
TRAF6-mediated innate immune activation is central to the inflammatory cytokine cascade that may be dysregulated in Long COVID.
Can a consumer DNA test detect the rs251457 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs251457 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for TRAF6 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32972995
- [2]Nature Genetics
- [3]Journal of Clinical Investigation