rs4803661
Variant in the TRIM25 gene (Tripartite Motif Containing 25)
rs4803661 is a single nucleotide polymorphism (SNP) in the TRIM25 gene, involved in RLR signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs4803661 variant?
rs4803661 is a SNP (single nucleotide polymorphism) in the TRIM25 (Tripartite Motif Containing 25) gene. It belongs to the Innate Immunity category and is part of the Innate Immunity & Interferons biological cluster. TRIM25 is an E3 ubiquitin ligase that ubiquitinates RIG-I CARDs to enable MAVS signaling. It is an important positive regulator of antiviral innate immunity and is targeted by multiple viral immune evasion proteins.
Biological role and pathway
This variant sits within the TRIM25 gene, which is involved in the RLR signaling pathway. Genes within the Innate Immunity & Interferons cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs4803661 and Long COVID / ME-CFS research
TRIM25 is antagonized by SARS-CoV-2 NSP15 endoribonuclease to suppress RIG-I activation. TRIM25 variants may affect the robustness of early antiviral responses, with implications for viral persistence and Long COVID susceptibility.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: TRIM25
rs4803661 is one of 3 known variants in the TRIM25 gene. To understand the full biological context of this variant, explore the parent gene page.
View TRIM25 gene page →Conditions studied in relation to rs4803661
Research into TRIM25 variants including rs4803661 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include TRIM25 and the rs4803661 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the TRIM25 gene
The following variants in TRIM25 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs4803661 variant in the TRIM25 gene?
rs4803661 is a single nucleotide polymorphism (SNP) located in the TRIM25 (Tripartite Motif Containing 25) gene, which is involved in RLR signaling. TRIM25 is an E3 ubiquitin ligase that ubiquitinates RIG-I CARDs to enable MAVS signaling. It is an important positive regulator of antiviral innate immunity and is targeted by multiple viral immune evasion proteins.
How may the rs4803661 variant relate to Long COVID or ME/CFS?
TRIM25 is antagonized by SARS-CoV-2 NSP15 endoribonuclease to suppress RIG-I activation. TRIM25 variants may affect the robustness of early antiviral responses, with implications for viral persistence and Long COVID susceptibility.
Can a consumer DNA test detect the rs4803661 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs4803661 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for TRIM25 and its variants. This is not an exhaustive literature review.
- [1]PMID: 27397234
- [2]Nature
- [3]Journal of Virology