rs3740996
Variant in the TRIM5 gene (Tripartite Motif Containing 5)
rs3740996 is a single nucleotide polymorphism (SNP) in the TRIM5 gene, involved in antiviral restriction. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs3740996 variant?
rs3740996 is a SNP (single nucleotide polymorphism) in the TRIM5 (Tripartite Motif Containing 5) gene. It belongs to the Innate Immunity category and is part of the Innate Immunity & Interferons biological cluster. TRIM5α is a cytoplasmic restriction factor that recognizes incoming retroviral capsid and targets the viral core for proteasomal degradation. It shows species-specific antiviral potency through SPRY domain variation.
Biological role and pathway
This variant sits within the TRIM5 gene, which is involved in the antiviral restriction pathway. Genes within the Innate Immunity & Interferons cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs3740996 and Long COVID / ME-CFS research
TRIM5 and related TRIM family proteins restrict diverse viruses and participate in antiviral innate immune signaling. TRIM family variants may influence the efficiency of SARS-CoV-2 sensing and clearance relevant to Long COVID pathogenesis.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: TRIM5
rs3740996 is one of 3 known variants in the TRIM5 gene. To understand the full biological context of this variant, explore the parent gene page.
View TRIM5 gene page →Conditions studied in relation to rs3740996
Research into TRIM5 variants including rs3740996 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include TRIM5 and the rs3740996 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the TRIM5 gene
The following variants in TRIM5 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs3740996 variant in the TRIM5 gene?
rs3740996 is a single nucleotide polymorphism (SNP) located in the TRIM5 (Tripartite Motif Containing 5) gene, which is involved in antiviral restriction. TRIM5α is a cytoplasmic restriction factor that recognizes incoming retroviral capsid and targets the viral core for proteasomal degradation. It shows species-specific antiviral potency through SPRY domain variation.
How may the rs3740996 variant relate to Long COVID or ME/CFS?
TRIM5 and related TRIM family proteins restrict diverse viruses and participate in antiviral innate immune signaling. TRIM family variants may influence the efficiency of SARS-CoV-2 sensing and clearance relevant to Long COVID pathogenesis.
Can a consumer DNA test detect the rs3740996 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs3740996 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for TRIM5 and its variants. This is not an exhaustive literature review.
- [1]PMID: 28262556
- [2]Nature
- [3]PNAS