rs13255063
Variant in the TRPA1 gene (Transient Receptor Potential Ankyrin 1)
rs13255063 is a single nucleotide polymorphism (SNP) in the TRPA1 gene, involved in nociception and sensory signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs13255063 variant?
rs13255063 is a SNP (single nucleotide polymorphism) in the TRPA1 (Transient Receptor Potential Ankyrin 1) gene. It belongs to the Pain Sensory category and is part of the Pain & Sensory Processing biological cluster. TRPA1 encodes a non-selective cation channel activated by cold, chemical irritants, and inflammatory mediators.
Biological role and pathway
This variant sits within the TRPA1 gene, which is involved in the nociception and sensory signaling pathway. Genes within the Pain & Sensory Processing cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs13255063 and Long COVID / ME-CFS research
TRPA1 sensitization by inflammatory cytokines may contribute to chemical hypersensitivity, airway symptoms, and pain amplification in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: TRPA1
rs13255063 is one of 2 known variants in the TRPA1 gene. To understand the full biological context of this variant, explore the parent gene page.
View TRPA1 gene page →Conditions studied in relation to rs13255063
Research into TRPA1 variants including rs13255063 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include TRPA1 and the rs13255063 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the TRPA1 gene
The following variants in TRPA1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs13255063 variant in the TRPA1 gene?
rs13255063 is a single nucleotide polymorphism (SNP) located in the TRPA1 (Transient Receptor Potential Ankyrin 1) gene, which is involved in nociception and sensory signaling. TRPA1 encodes a non-selective cation channel activated by cold, chemical irritants, and inflammatory mediators.
How may the rs13255063 variant relate to Long COVID or ME/CFS?
TRPA1 sensitization by inflammatory cytokines may contribute to chemical hypersensitivity, airway symptoms, and pain amplification in Long COVID.
Can a consumer DNA test detect the rs13255063 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs13255063 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for TRPA1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32272069
- [2]Nature Genetics
- [3]Journal of Clinical Investigation