rs10166942
Variant in the TRPM8 gene (Transient Receptor Potential Cation Channel Subfamily M Member 8)
rs10166942 is a single nucleotide polymorphism (SNP) in the TRPM8 gene, involved in cold thermosensation / migraine. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs10166942 variant?
rs10166942 is a SNP (single nucleotide polymorphism) in the TRPM8 (Transient Receptor Potential Cation Channel Subfamily M Member 8) gene. It belongs to the Neurological category and is part of the Neurological & Cognitive Function biological cluster. TRPM8 encodes the primary cold and menthol receptor on sensory neurons, mediating cool/cold temperature sensation.
Biological role and pathway
This variant sits within the TRPM8 gene, which is involved in the cold thermosensation / migraine pathway. Genes within the Neurological & Cognitive Function cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs10166942 and Long COVID / ME-CFS research
TRPM8 is the dominant migraine susceptibility gene (rs10166942); cold sensitivity, abnormal thermosensation, and migraine are reported in Long COVID, with TRPM8 variants potentially contributing.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: TRPM8
rs10166942 is one of 2 known variants in the TRPM8 gene. To understand the full biological context of this variant, explore the parent gene page.
View TRPM8 gene page →Conditions studied in relation to rs10166942
Research into TRPM8 variants including rs10166942 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include TRPM8 and the rs10166942 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the TRPM8 gene
The following variants in TRPM8 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs10166942 variant in the TRPM8 gene?
rs10166942 is a single nucleotide polymorphism (SNP) located in the TRPM8 (Transient Receptor Potential Cation Channel Subfamily M Member 8) gene, which is involved in cold thermosensation / migraine. TRPM8 encodes the primary cold and menthol receptor on sensory neurons, mediating cool/cold temperature sensation.
How may the rs10166942 variant relate to Long COVID or ME/CFS?
TRPM8 is the dominant migraine susceptibility gene (rs10166942); cold sensitivity, abnormal thermosensation, and migraine are reported in Long COVID, with TRPM8 variants potentially contributing.
Can a consumer DNA test detect the rs10166942 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs10166942 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for TRPM8 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33664986
- [2]Nature Genetics
- [3]Nature Neuroscience