rs222747

What is the rs222747 variant?

rs222747 is a SNP (single nucleotide polymorphism) in the TRPV1 (Transient Receptor Potential Vanilloid 1) gene. It belongs to the Pain Sensory category and is part of the Pain & Sensory Processing biological cluster. TRPV1 encodes a non-selective cation channel activated by heat, capsaicin, and pro-inflammatory mediators, central to pain transduction.

Biological role and pathway

This variant sits within the TRPV1 gene, which is involved in the pain and sensory signaling pathway. Genes within the Pain & Sensory Processing cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: TRPV1

rs222747 is one of 2 known variants in the TRPV1 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs222747

Research into TRPV1 variants including rs222747 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include TRPV1 and the rs222747 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the TRPV1 gene

The following variants in TRPV1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions