rs2461028

What is the rs2461028 variant?

rs2461028 is a SNP (single nucleotide polymorphism) in the TSC1 (TSC Complex Subunit 1 (Hamartin)) gene. It belongs to the Signaling category and is part of the Cellular Signaling biological cluster. TSC1 encodes hamartin, which forms a complex with TSC2 to inhibit mTORC1 signaling and regulate cell growth.

Biological role and pathway

This variant sits within the TSC1 gene, which is involved in the mTORC1 regulation pathway. Genes within the Cellular Signaling cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: TSC1

rs2461028 is one of 1 known variant in the TSC1 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs2461028

Research into TSC1 variants including rs2461028 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include TSC1 and the rs2461028 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions