rs2284720
Variant in the TSHR gene (Thyroid Stimulating Hormone Receptor)
rs2284720 is a single nucleotide polymorphism (SNP) in the TSHR gene, involved in TSH signaling / thyroid function. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2284720 variant?
rs2284720 is a SNP (single nucleotide polymorphism) in the TSHR (Thyroid Stimulating Hormone Receptor) gene. It belongs to the Neuroendocrine category and is part of the Metabolic Regulation biological cluster. TSHR encodes the TSH receptor, which mediates pituitary TSH stimulation of thyroid hormone synthesis and release.
Biological role and pathway
This variant sits within the TSHR gene, which is involved in the TSH signaling / thyroid function pathway. Genes within the Metabolic Regulation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2284720 and Long COVID / ME-CFS research
TSHR autoantibodies can cause hyperthyroidism (Graves) or hypothyroidism; COVID-19 can trigger thyroid autoimmunity, with TSHR variants affecting susceptibility to post-COVID thyroid dysfunction in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: TSHR
rs2284720 is one of 2 known variants in the TSHR gene. To understand the full biological context of this variant, explore the parent gene page.
View TSHR gene page →Conditions studied in relation to rs2284720
Research into TSHR variants including rs2284720 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include TSHR and the rs2284720 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the TSHR gene
The following variants in TSHR are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2284720 variant in the TSHR gene?
rs2284720 is a single nucleotide polymorphism (SNP) located in the TSHR (Thyroid Stimulating Hormone Receptor) gene, which is involved in TSH signaling / thyroid function. TSHR encodes the TSH receptor, which mediates pituitary TSH stimulation of thyroid hormone synthesis and release.
How may the rs2284720 variant relate to Long COVID or ME/CFS?
TSHR autoantibodies can cause hyperthyroidism (Graves) or hypothyroidism; COVID-19 can trigger thyroid autoimmunity, with TSHR variants affecting susceptibility to post-COVID thyroid dysfunction in Long COVID.
Can a consumer DNA test detect the rs2284720 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2284720 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for TSHR and its variants. This is not an exhaustive literature review.
- [1]PMID: 33664986
- [2]Nature Genetics
- [3]NEJM