rs2289276
Variant in the TSLP gene (Thymic Stromal Lymphopoietin)
rs2289276 is a single nucleotide polymorphism (SNP) in the TSLP gene, involved in alarmin signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2289276 variant?
rs2289276 is a SNP (single nucleotide polymorphism) in the TSLP (Thymic Stromal Lymphopoietin) gene. It belongs to the Immune Signaling category and is part of the Immune System & Inflammation biological cluster. TSLP is an epithelial-derived alarmin cytokine that activates dendritic cells, mast cells, and ILC2s to promote Th2 immune responses and atopic disease. It is produced in response to barrier damage and sensed by TSLPR (IL7R/CRLF2 complex).
Biological role and pathway
This variant sits within the TSLP gene, which is involved in the alarmin signaling pathway. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2289276 and Long COVID / ME-CFS research
TSLP contributes to airway hyper-responsiveness and atopic inflammation. In Long COVID, persistent airway inflammation and cough may involve TSLP-driven ILC2 activation. TSLP variants affecting basal epithelial alarmin production may predispose to respiratory Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: TSLP
rs2289276 is one of 3 known variants in the TSLP gene. To understand the full biological context of this variant, explore the parent gene page.
View TSLP gene page →Conditions studied in relation to rs2289276
Research into TSLP variants including rs2289276 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include TSLP and the rs2289276 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the TSLP gene
The following variants in TSLP are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2289276 variant in the TSLP gene?
rs2289276 is a single nucleotide polymorphism (SNP) located in the TSLP (Thymic Stromal Lymphopoietin) gene, which is involved in alarmin signaling. TSLP is an epithelial-derived alarmin cytokine that activates dendritic cells, mast cells, and ILC2s to promote Th2 immune responses and atopic disease. It is produced in response to barrier damage and sensed by TSLPR (IL7R/CRLF2 complex).
How may the rs2289276 variant relate to Long COVID or ME/CFS?
TSLP contributes to airway hyper-responsiveness and atopic inflammation. In Long COVID, persistent airway inflammation and cough may involve TSLP-driven ILC2 activation. TSLP variants affecting basal epithelial alarmin production may predispose to respiratory Long COVID.
Can a consumer DNA test detect the rs2289276 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2289276 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for TSLP and its variants. This is not an exhaustive literature review.
- [1]PMID: 30643716
- [2]New England Journal of Medicine
- [3]Nature Immunology