rs8756

What is the rs8756 variant?

rs8756 is a SNP (single nucleotide polymorphism) in the TYROBP (TYRO Protein Tyrosine Kinase Binding Protein (DAP12)) gene. It belongs to the Immune Signaling category and is part of the Neurological & Cognitive Function biological cluster. TYROBP encodes DAP12, the signaling adaptor for TREM2 and other immunoreceptors on microglia and NK cells.

Biological role and pathway

This variant sits within the TYROBP gene, which is involved in the TREM2 co-receptor / microglial signaling pathway. Genes within the Neurological & Cognitive Function cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: TYROBP

rs8756 is one of 1 known variant in the TYROBP gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs8756

Research into TYROBP variants including rs8756 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include TYROBP and the rs8756 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions