rs9924987
Variant in the UNC93B1 gene (Unc-93 Homolog B1, TLR Signaling Regulator)
rs9924987 is a single nucleotide polymorphism (SNP) in the UNC93B1 gene, involved in TLR signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs9924987 variant?
rs9924987 is a SNP (single nucleotide polymorphism) in the UNC93B1 (Unc-93 Homolog B1, TLR Signaling Regulator) gene. It belongs to the Innate Immunity category and is part of the Innate Immunity & Interferons biological cluster. UNC93B1 is an endoplasmic reticulum membrane protein that escorts TLR3, 7, 8, and 9 from ER to endolysosomes for viral sensing. Loss-of-function mutations cause herpes simplex encephalitis through TLR3 pathway disruption.
Biological role and pathway
This variant sits within the UNC93B1 gene, which is involved in the TLR signaling pathway. Genes within the Innate Immunity & Interferons cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs9924987 and Long COVID / ME-CFS research
UNC93B1 mutations reveal the critical role of endosomal TLR signaling in SARS-CoV-2 RNA sensing. Hypomorphic UNC93B1 variants may impair early viral detection, while hyperactive variants (D34A) drive autoimmunity through excess endosomal TLR activation.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: UNC93B1
rs9924987 is one of 3 known variants in the UNC93B1 gene. To understand the full biological context of this variant, explore the parent gene page.
View UNC93B1 gene page →Conditions studied in relation to rs9924987
Research into UNC93B1 variants including rs9924987 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include UNC93B1 and the rs9924987 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the UNC93B1 gene
The following variants in UNC93B1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs9924987 variant in the UNC93B1 gene?
rs9924987 is a single nucleotide polymorphism (SNP) located in the UNC93B1 (Unc-93 Homolog B1, TLR Signaling Regulator) gene, which is involved in TLR signaling. UNC93B1 is an endoplasmic reticulum membrane protein that escorts TLR3, 7, 8, and 9 from ER to endolysosomes for viral sensing. Loss-of-function mutations cause herpes simplex encephalitis through TLR3 pathway disruption.
How may the rs9924987 variant relate to Long COVID or ME/CFS?
UNC93B1 mutations reveal the critical role of endosomal TLR signaling in SARS-CoV-2 RNA sensing. Hypomorphic UNC93B1 variants may impair early viral detection, while hyperactive variants (D34A) drive autoimmunity through excess endosomal TLR activation.
Can a consumer DNA test detect the rs9924987 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs9924987 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for UNC93B1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 25284119
- [2]Science
- [3]Journal of Experimental Medicine