rs1409419
Variant in the VCAM1 gene (Vascular Cell Adhesion Molecule 1)
rs1409419 is a single nucleotide polymorphism (SNP) in the VCAM1 gene, involved in leukocyte adhesion. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1409419 variant?
rs1409419 is a SNP (single nucleotide polymorphism) in the VCAM1 (Vascular Cell Adhesion Molecule 1) gene. It belongs to the Cell Adhesion category and is part of the Coagulation & Vascular biological cluster. VCAM-1 is an endothelial adhesion molecule induced by TNF, IL-1, and IL-6 that binds VLA-4 (α4β1) to mediate leukocyte adhesion and transmigration. Soluble VCAM-1 is a biomarker of endothelial activation and vascular inflammation.
Biological role and pathway
This variant sits within the VCAM1 gene, which is involved in the leukocyte adhesion pathway. Genes within the Coagulation & Vascular cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1409419 and Long COVID / ME-CFS research
VCAM-1 is persistently elevated in Long COVID patients as a marker of endothelial activation. VCAM1 variants affecting basal and inducible expression may influence the degree of endothelial activation and leukocyte extravasation contributing to Long COVID vascular pathology.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: VCAM1
rs1409419 is one of 3 known variants in the VCAM1 gene. To understand the full biological context of this variant, explore the parent gene page.
View VCAM1 gene page →Conditions studied in relation to rs1409419
Research into VCAM1 variants including rs1409419 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include VCAM1 and the rs1409419 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the VCAM1 gene
The following variants in VCAM1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1409419 variant in the VCAM1 gene?
rs1409419 is a single nucleotide polymorphism (SNP) located in the VCAM1 (Vascular Cell Adhesion Molecule 1) gene, which is involved in leukocyte adhesion. VCAM-1 is an endothelial adhesion molecule induced by TNF, IL-1, and IL-6 that binds VLA-4 (α4β1) to mediate leukocyte adhesion and transmigration. Soluble VCAM-1 is a biomarker of endothelial activation and vascular inflammation.
How may the rs1409419 variant relate to Long COVID or ME/CFS?
VCAM-1 is persistently elevated in Long COVID patients as a marker of endothelial activation. VCAM1 variants affecting basal and inducible expression may influence the degree of endothelial activation and leukocyte extravasation contributing to Long COVID vascular pathology.
Can a consumer DNA test detect the rs1409419 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1409419 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for VCAM1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33691833
- [2]Cell
- [3]Nature Medicine