rs3025039
Variant in the VEGFA gene (Vascular Endothelial Growth Factor A)
rs3025039 is a single nucleotide polymorphism (SNP) in the VEGFA gene, involved in angiogenesis / vascular permeability. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs3025039 variant?
rs3025039 is a SNP (single nucleotide polymorphism) in the VEGFA (Vascular Endothelial Growth Factor A) gene. It belongs to the Vascular category and is part of the Coagulation & Microcirculation biological cluster. VEGFA encodes vascular endothelial growth factor A, the primary mediator of angiogenesis and vascular permeability.
Biological role and pathway
This variant sits within the VEGFA gene, which is involved in the angiogenesis / vascular permeability pathway. Genes within the Coagulation & Microcirculation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs3025039 and Long COVID / ME-CFS research
VEGFA is elevated in COVID-19 and Long COVID, contributing to vascular hyperpermeability and endothelial dysfunction; variants may affect the severity of vascular complications.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: VEGFA
rs3025039 is one of 3 known variants in the VEGFA gene. To understand the full biological context of this variant, explore the parent gene page.
View VEGFA gene page →Conditions studied in relation to rs3025039
Research into VEGFA variants including rs3025039 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include VEGFA and the rs3025039 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the VEGFA gene
The following variants in VEGFA are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs3025039 variant in the VEGFA gene?
rs3025039 is a single nucleotide polymorphism (SNP) located in the VEGFA (Vascular Endothelial Growth Factor A) gene, which is involved in angiogenesis / vascular permeability. VEGFA encodes vascular endothelial growth factor A, the primary mediator of angiogenesis and vascular permeability.
How may the rs3025039 variant relate to Long COVID or ME/CFS?
VEGFA is elevated in COVID-19 and Long COVID, contributing to vascular hyperpermeability and endothelial dysfunction; variants may affect the severity of vascular complications.
Can a consumer DNA test detect the rs3025039 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs3025039 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for VEGFA and its variants. This is not an exhaustive literature review.
- [1]PMID: 32966261
- [2]Nature Medicine
- [3]Journal of Clinical Investigation