rs6453645

What is the rs6453645 variant?

rs6453645 is a SNP (single nucleotide polymorphism) in the VEGFB (Vascular Endothelial Growth Factor B) gene. It belongs to the Vascular category and is part of the Coagulation & Microcirculation biological cluster. VEGFB encodes a vascular growth factor that promotes cardiac muscle growth and fatty acid transport rather than angiogenesis.

Biological role and pathway

This variant sits within the VEGFB gene, which is involved in the cardiac vascular growth pathway. Genes within the Coagulation & Microcirculation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: VEGFB

rs6453645 is one of 1 known variant in the VEGFB gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs6453645

Research into VEGFB variants including rs6453645 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include VEGFB and the rs6453645 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions