rs779805

What is the rs779805 variant?

rs779805 is a SNP (single nucleotide polymorphism) in the VHL (Von Hippel-Lindau Tumor Suppressor) gene. It belongs to the Signaling category and is part of the Mitochondrial Energy Production & PEM biological cluster. VHL encodes the substrate recognition component of an E3 ubiquitin ligase that targets HIF-alpha for proteasomal degradation under normoxia.

Biological role and pathway

This variant sits within the VHL gene, which is involved in the HIF-alpha ubiquitination / oxygen sensing pathway. Genes within the Mitochondrial Energy Production & PEM cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: VHL

rs779805 is one of 1 known variant in the VHL gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs779805

Research into VHL variants including rs779805 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include VHL and the rs779805 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions