rs11672725

Variant in the VIP gene (Vasoactive Intestinal Peptide)

rs11672725 is a single nucleotide polymorphism (SNP) in the VIP gene, involved in gut motility / immune modulation / vasodilation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.

This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.

What is the rs11672725 variant?

rs11672725 is a SNP (single nucleotide polymorphism) in the VIP (Vasoactive Intestinal Peptide) gene. It belongs to the Neuroendocrine category and is part of the Autonomic Nervous System biological cluster. VIP encodes vasoactive intestinal peptide, a neuropeptide with potent vasodilatory, anti-inflammatory, and gut motility-regulating effects.

Biological role and pathway

This variant sits within the VIP gene, which is involved in the gut motility / immune modulation / vasodilation pathway. Genes within the Autonomic Nervous System cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

rs11672725 and Long COVID / ME-CFS research

VIP has anti-inflammatory and immunomodulatory effects; deficiency or dysregulation may contribute to gut dysmotility, vascular dysfunction, and neuroinflammation in Long COVID.

This information is based on published research and does not constitute medical advice. See references below.

Parent gene: VIP

rs11672725 is one of 1 known variant in the VIP gene. To understand the full biological context of this variant, explore the parent gene page.

View VIP gene page →

Conditions studied in relation to rs11672725

Research into VIP variants including rs11672725 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include VIP and the rs11672725 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions

What is the rs11672725 variant in the VIP gene?

rs11672725 is a single nucleotide polymorphism (SNP) located in the VIP (Vasoactive Intestinal Peptide) gene, which is involved in gut motility / immune modulation / vasodilation. VIP encodes vasoactive intestinal peptide, a neuropeptide with potent vasodilatory, anti-inflammatory, and gut motility-regulating effects.

How may the rs11672725 variant relate to Long COVID or ME/CFS?

VIP has anti-inflammatory and immunomodulatory effects; deficiency or dysregulation may contribute to gut dysmotility, vascular dysfunction, and neuroinflammation in Long COVID.

Can a consumer DNA test detect the rs11672725 variant?

Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.

Find out if you carry the rs11672725 variant

Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.

Get Your Personalised DNA Report

Informational and educational only · Not a diagnostic tool · GDPR compliant

References

The following publications were used in compiling the research context for VIP and its variants. This is not an exhaustive literature review.

  • [1]PMID: 33664986
  • [2]Nature Genetics
  • [3]Journal of Neuroimmunology