rs1800378
Variant in the VWF gene (Von Willebrand Factor)
rs1800378 is a single nucleotide polymorphism (SNP) in the VWF gene, involved in platelet adhesion and coagulation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1800378 variant?
rs1800378 is a SNP (single nucleotide polymorphism) in the VWF (Von Willebrand Factor) gene. It belongs to the Coagulation category and is part of the Coagulation & Microcirculation biological cluster. VWF encodes von Willebrand factor, a multimeric glycoprotein essential for platelet adhesion and as a carrier for clotting factor VIII.
Biological role and pathway
This variant sits within the VWF gene, which is involved in the platelet adhesion and coagulation pathway. Genes within the Coagulation & Microcirculation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1800378 and Long COVID / ME-CFS research
Elevated VWF and endothelial activation markers have been documented in Long COVID, reflecting vascular injury and persistent endotheliopathy.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: VWF
rs1800378 is one of 3 known variants in the VWF gene. To understand the full biological context of this variant, explore the parent gene page.
View VWF gene page →Conditions studied in relation to rs1800378
Research into VWF variants including rs1800378 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include VWF and the rs1800378 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the VWF gene
The following variants in VWF are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1800378 variant in the VWF gene?
rs1800378 is a single nucleotide polymorphism (SNP) located in the VWF (Von Willebrand Factor) gene, which is involved in platelet adhesion and coagulation. VWF encodes von Willebrand factor, a multimeric glycoprotein essential for platelet adhesion and as a carrier for clotting factor VIII.
How may the rs1800378 variant relate to Long COVID or ME/CFS?
Elevated VWF and endothelial activation markers have been documented in Long COVID, reflecting vascular injury and persistent endotheliopathy.
Can a consumer DNA test detect the rs1800378 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1800378 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for VWF and its variants. This is not an exhaustive literature review.
- [1]PMID: 34316049
- [2]Nature Genetics
- [3]Journal of Clinical Investigation