rs566926

What is the rs566926 variant?

rs566926 is a SNP (single nucleotide polymorphism) in the WNT5A (Wnt Family Member 5A) gene. It belongs to the Signaling category and is part of the Immune System & Inflammation biological cluster. WNT5A encodes a Wnt ligand that activates non-canonical Wnt/ROR2 signaling, promoting macrophage inflammatory activation.

Biological role and pathway

This variant sits within the WNT5A gene, which is involved in the non-canonical Wnt signaling / inflammation pathway. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: WNT5A

rs566926 is one of 1 known variant in the WNT5A gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs566926

Research into WNT5A variants including rs566926 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include WNT5A and the rs566926 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions