ABCC2 Gene
ATP Binding Cassette Subfamily C Member 2 (ABCC2) is a gene involved in drug transport that has been studied in relation to immune function, metabolism, and chronic illness. Variants in ABCC2 may influence how the body responds to infection, inflammation, and long-term recovery.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the ABCC2 gene?
ABCC2 encodes atp binding cassette subfamily c member 2, a protein involved in drug transport. It belongs to the Metabolism category and is part of the Pharmacogenomics biological cluster. ABCC2 (MRP2) is an ABC transporter that exports organic anions, glucuronide/glutathione conjugates, and drugs from hepatocytes, enterocytes, and renal tubules. Variants affect drug pharmacokinetics and bilirubin transport.
Biological role and pathway
ABCC2 is involved in the drug transport pathway, which plays a central role in regulating physiological processes relevant to immune defence, cellular energy, and systemic homeostasis. Genes within the Pharmacogenomics cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function in these systems — particularly under conditions of physiological stress such as viral infection or prolonged illness.
ABCC2 and Long COVID / ME-CFS research
ABCC2 variants affecting drug efflux may alter pharmacokinetics of antivirals and other treatments used in COVID-19 and Long COVID. Impaired ABCC2 function also affects bile acid and bilirubin clearance relevant to liver complications in COVID-19.
This information is based on published research and does not constitute medical advice. See references below.
Known genetic variants
The following variants (SNPs) in the ABCC2 gene have been studied in relation to metabolism and chronic illness. Each variant represents a single nucleotide position where individuals may carry different alleles.
Conditions studied in relation to ABCC2
Research into ABCC2 variants has explored associations with the following conditions. These are areas of scientific investigation and do not imply that ABCC2 causes or treats any condition.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include ABCC2 and related genes in the pharmacogenomics pathway.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Related genes in the Pharmacogenomics pathway
ABCC2 does not act in isolation. The following genes are functionally related and may be analysed together for a more complete picture of your genetic predispositions.
Frequently asked questions
What is the ABCC2 gene and what does it do?
ABCC2 (ATP Binding Cassette Subfamily C Member 2) is involved in drug transport. ABCC2 (MRP2) is an ABC transporter that exports organic anions, glucuronide/glutathione conjugates, and drugs from hepatocytes, enterocytes, and renal tubules. Variants affect drug pharmacokinetics and bilirubin transport.
How may ABCC2 gene variants relate to Long COVID or ME/CFS?
ABCC2 variants affecting drug efflux may alter pharmacokinetics of antivirals and other treatments used in COVID-19 and Long COVID. Impaired ABCC2 function also affects bile acid and bilirubin clearance relevant to liver complications in COVID-19.
Can a DNA test reveal information about my ABCC2 gene?
Consumer DNA data from 23andMe, AncestryDNA, and MyHeritage includes SNP variants for many genes. ChronicDNA analyses your raw DNA file and reports on variants that have been studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Explore your ABCC2 genetic insights
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for ABCC2. This is not an exhaustive literature review.
- [1]PMID: 26864345
- [2]Clinical Pharmacology & Therapeutics
- [3]Drug Metabolism and Pharmacokinetics