rs717620
Variant in the ABCC2 gene (ATP Binding Cassette Subfamily C Member 2)
rs717620 is a single nucleotide polymorphism (SNP) in the ABCC2 gene, involved in drug transport. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs717620 variant?
rs717620 is a SNP (single nucleotide polymorphism) in the ABCC2 (ATP Binding Cassette Subfamily C Member 2) gene. It belongs to the Metabolism category and is part of the Pharmacogenomics biological cluster. ABCC2 (MRP2) is an ABC transporter that exports organic anions, glucuronide/glutathione conjugates, and drugs from hepatocytes, enterocytes, and renal tubules. Variants affect drug pharmacokinetics and bilirubin transport.
Biological role and pathway
This variant sits within the ABCC2 gene, which is involved in the drug transport pathway. Genes within the Pharmacogenomics cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs717620 and Long COVID / ME-CFS research
ABCC2 variants affecting drug efflux may alter pharmacokinetics of antivirals and other treatments used in COVID-19 and Long COVID. Impaired ABCC2 function also affects bile acid and bilirubin clearance relevant to liver complications in COVID-19.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: ABCC2
rs717620 is one of 3 known variants in the ABCC2 gene. To understand the full biological context of this variant, explore the parent gene page.
View ABCC2 gene page →Conditions studied in relation to rs717620
Research into ABCC2 variants including rs717620 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include ABCC2 and the rs717620 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the ABCC2 gene
The following variants in ABCC2 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs717620 variant in the ABCC2 gene?
rs717620 is a single nucleotide polymorphism (SNP) located in the ABCC2 (ATP Binding Cassette Subfamily C Member 2) gene, which is involved in drug transport. ABCC2 (MRP2) is an ABC transporter that exports organic anions, glucuronide/glutathione conjugates, and drugs from hepatocytes, enterocytes, and renal tubules. Variants affect drug pharmacokinetics and bilirubin transport.
How may the rs717620 variant relate to Long COVID or ME/CFS?
ABCC2 variants affecting drug efflux may alter pharmacokinetics of antivirals and other treatments used in COVID-19 and Long COVID. Impaired ABCC2 function also affects bile acid and bilirubin clearance relevant to liver complications in COVID-19.
Can a consumer DNA test detect the rs717620 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs717620 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for ABCC2 and its variants. This is not an exhaustive literature review.
- [1]PMID: 26864345
- [2]Clinical Pharmacology & Therapeutics
- [3]Drug Metabolism and Pharmacokinetics