ADRB3 Gene

What is the ADRB3 gene?

ADRB3 encodes adrenoceptor beta 3, a protein involved in adrenergic lipolysis / thermogenesis. It belongs to the Metabolic category and is part of the Metabolic Regulation biological cluster. ADRB3 encodes the beta-3 adrenergic receptor on adipose tissue and bladder, mediating lipolysis, thermogenesis, and detrusor relaxation.

Biological role and pathway

ADRB3 is involved in the adrenergic lipolysis / thermogenesis pathway, which plays a central role in regulating physiological processes relevant to immune defence, cellular energy, and systemic homeostasis. Genes within the Metabolic Regulation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function in these systems — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Known genetic variants

The following variants (SNPs) in the ADRB3 gene have been studied in relation to metabolic and chronic illness. Each variant represents a single nucleotide position where individuals may carry different alleles.

• rs4994— ADRB3 variant

Conditions studied in relation to ADRB3

Research into ADRB3 variants has explored associations with the following conditions. These are areas of scientific investigation and do not imply that ADRB3 causes or treats any condition.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include ADRB3 and related genes in the metabolic regulation pathway.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Related genes in the Metabolic Regulation pathway

ADRB3 does not act in isolation. The following genes are functionally related and may be analysed together for a more complete picture of your genetic predispositions.

Frequently asked questions