AKT1 Gene

What is the AKT1 gene?

AKT1 encodes akt serine/threonine kinase 1, a protein involved in PI3K-AKT signaling. It belongs to the Signaling category and is part of the Cellular Signaling biological cluster. AKT1 encodes a serine/threonine kinase central to cell survival, glucose metabolism, and immune cell activation downstream of PI3K.

Biological role and pathway

AKT1 is involved in the PI3K-AKT signaling pathway, which plays a central role in regulating physiological processes relevant to immune defence, cellular energy, and systemic homeostasis. Genes within the Cellular Signaling cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function in these systems — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Known genetic variants

The following variants (SNPs) in the AKT1 gene have been studied in relation to signaling and chronic illness. Each variant represents a single nucleotide position where individuals may carry different alleles.

• rs2494732— AKT1 variant
• rs1130233— AKT1 variant

Conditions studied in relation to AKT1

Research into AKT1 variants has explored associations with the following conditions. These are areas of scientific investigation and do not imply that AKT1 causes or treats any condition.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include AKT1 and related genes in the cellular signaling pathway.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Related genes in the Cellular Signaling pathway

AKT1 does not act in isolation. The following genes are functionally related and may be analysed together for a more complete picture of your genetic predispositions.

Frequently asked questions