rs1130233
Variant in the AKT1 gene (AKT Serine/Threonine Kinase 1)
rs1130233 is a single nucleotide polymorphism (SNP) in the AKT1 gene, involved in PI3K-AKT signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1130233 variant?
rs1130233 is a SNP (single nucleotide polymorphism) in the AKT1 (AKT Serine/Threonine Kinase 1) gene. It belongs to the Signaling category and is part of the Cellular Signaling biological cluster. AKT1 encodes a serine/threonine kinase central to cell survival, glucose metabolism, and immune cell activation downstream of PI3K.
Biological role and pathway
This variant sits within the AKT1 gene, which is involved in the PI3K-AKT signaling pathway. Genes within the Cellular Signaling cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1130233 and Long COVID / ME-CFS research
AKT1 pathway activation is involved in T cell activation and mast cell signaling, both of which are dysregulated in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: AKT1
rs1130233 is one of 2 known variants in the AKT1 gene. To understand the full biological context of this variant, explore the parent gene page.
View AKT1 gene page →Conditions studied in relation to rs1130233
Research into AKT1 variants including rs1130233 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include AKT1 and the rs1130233 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the AKT1 gene
The following variants in AKT1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1130233 variant in the AKT1 gene?
rs1130233 is a single nucleotide polymorphism (SNP) located in the AKT1 (AKT Serine/Threonine Kinase 1) gene, which is involved in PI3K-AKT signaling. AKT1 encodes a serine/threonine kinase central to cell survival, glucose metabolism, and immune cell activation downstream of PI3K.
How may the rs1130233 variant relate to Long COVID or ME/CFS?
AKT1 pathway activation is involved in T cell activation and mast cell signaling, both of which are dysregulated in Long COVID.
Can a consumer DNA test detect the rs1130233 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1130233 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for AKT1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 34316049
- [2]Nature Genetics
- [3]Journal of Clinical Investigation