CD14 Gene

What is the CD14 gene?

CD14 encodes cd14 molecule (lps receptor), a protein involved in LPS sensing / macrophage activation. It belongs to the Immune Signaling category and is part of the Immune System & Inflammation biological cluster. CD14 encodes a co-receptor for LPS sensing on monocytes and macrophages, working with TLR4 and MD-2 to detect bacterial endotoxin.

Biological role and pathway

CD14 is involved in the LPS sensing / macrophage activation pathway, which plays a central role in regulating physiological processes relevant to immune defence, cellular energy, and systemic homeostasis. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function in these systems — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Known genetic variants

The following variants (SNPs) in the CD14 gene have been studied in relation to immune signaling and chronic illness. Each variant represents a single nucleotide position where individuals may carry different alleles.

• rs2569190— CD14 variant
• rs4914— CD14 variant

Conditions studied in relation to CD14

Research into CD14 variants has explored associations with the following conditions. These are areas of scientific investigation and do not imply that CD14 causes or treats any condition.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include CD14 and related genes in the immune system & inflammation pathway.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Related genes in the Immune System & Inflammation pathway

CD14 does not act in isolation. The following genes are functionally related and may be analysed together for a more complete picture of your genetic predispositions.

Frequently asked questions