rs2569190
Variant in the CD14 gene (CD14 Molecule (LPS Receptor))
rs2569190 is a single nucleotide polymorphism (SNP) in the CD14 gene, involved in LPS sensing / macrophage activation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2569190 variant?
rs2569190 is a SNP (single nucleotide polymorphism) in the CD14 (CD14 Molecule (LPS Receptor)) gene. It belongs to the Immune Signaling category and is part of the Immune System & Inflammation biological cluster. CD14 encodes a co-receptor for LPS sensing on monocytes and macrophages, working with TLR4 and MD-2 to detect bacterial endotoxin.
Biological role and pathway
This variant sits within the CD14 gene, which is involved in the LPS sensing / macrophage activation pathway. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2569190 and Long COVID / ME-CFS research
CD14-mediated LPS sensing drives macrophage activation; gut microbiome dysbiosis in Long COVID may increase systemic LPS, with CD14 variants affecting macrophage inflammatory responses.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: CD14
rs2569190 is one of 2 known variants in the CD14 gene. To understand the full biological context of this variant, explore the parent gene page.
View CD14 gene page →Conditions studied in relation to rs2569190
Research into CD14 variants including rs2569190 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include CD14 and the rs2569190 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the CD14 gene
The following variants in CD14 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2569190 variant in the CD14 gene?
rs2569190 is a single nucleotide polymorphism (SNP) located in the CD14 (CD14 Molecule (LPS Receptor)) gene, which is involved in LPS sensing / macrophage activation. CD14 encodes a co-receptor for LPS sensing on monocytes and macrophages, working with TLR4 and MD-2 to detect bacterial endotoxin.
How may the rs2569190 variant relate to Long COVID or ME/CFS?
CD14-mediated LPS sensing drives macrophage activation; gut microbiome dysbiosis in Long COVID may increase systemic LPS, with CD14 variants affecting macrophage inflammatory responses.
Can a consumer DNA test detect the rs2569190 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2569190 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for CD14 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32296168
- [2]Nature Genetics
- [3]Journal of Immunology