CREB1 Gene

What is the CREB1 gene?

CREB1 encodes camp responsive element binding protein 1, a protein involved in cAMP/PKA / synaptic plasticity. It belongs to the Neurological category and is part of the Neurological & Cognitive Function biological cluster. CREB1 encodes CREB, a transcription factor activated by cAMP signaling that drives expression of plasticity-related genes including BDNF.

Biological role and pathway

CREB1 is involved in the cAMP/PKA / synaptic plasticity pathway, which plays a central role in regulating physiological processes relevant to immune defence, cellular energy, and systemic homeostasis. Genes within the Neurological & Cognitive Function cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function in these systems — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Known genetic variants

The following variants (SNPs) in the CREB1 gene have been studied in relation to neurological and chronic illness. Each variant represents a single nucleotide position where individuals may carry different alleles.

• rs2253206— CREB1 variant
• rs4675690— CREB1 variant

Conditions studied in relation to CREB1

Research into CREB1 variants has explored associations with the following conditions. These are areas of scientific investigation and do not imply that CREB1 causes or treats any condition.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include CREB1 and related genes in the neurological & cognitive function pathway.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Related genes in the Neurological & Cognitive Function pathway

CREB1 does not act in isolation. The following genes are functionally related and may be analysed together for a more complete picture of your genetic predispositions.

Frequently asked questions