rs2253206
Variant in the CREB1 gene (CAMP Responsive Element Binding Protein 1)
rs2253206 is a single nucleotide polymorphism (SNP) in the CREB1 gene, involved in cAMP/PKA / synaptic plasticity. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2253206 variant?
rs2253206 is a SNP (single nucleotide polymorphism) in the CREB1 (CAMP Responsive Element Binding Protein 1) gene. It belongs to the Neurological category and is part of the Neurological & Cognitive Function biological cluster. CREB1 encodes CREB, a transcription factor activated by cAMP signaling that drives expression of plasticity-related genes including BDNF.
Biological role and pathway
This variant sits within the CREB1 gene, which is involved in the cAMP/PKA / synaptic plasticity pathway. Genes within the Neurological & Cognitive Function cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2253206 and Long COVID / ME-CFS research
CREB-mediated gene expression is essential for memory consolidation and synaptic plasticity; CREB1 variants may affect cognitive resilience and recovery from brain fog in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: CREB1
rs2253206 is one of 2 known variants in the CREB1 gene. To understand the full biological context of this variant, explore the parent gene page.
View CREB1 gene page →Conditions studied in relation to rs2253206
Research into CREB1 variants including rs2253206 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include CREB1 and the rs2253206 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the CREB1 gene
The following variants in CREB1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2253206 variant in the CREB1 gene?
rs2253206 is a single nucleotide polymorphism (SNP) located in the CREB1 (CAMP Responsive Element Binding Protein 1) gene, which is involved in cAMP/PKA / synaptic plasticity. CREB1 encodes CREB, a transcription factor activated by cAMP signaling that drives expression of plasticity-related genes including BDNF.
How may the rs2253206 variant relate to Long COVID or ME/CFS?
CREB-mediated gene expression is essential for memory consolidation and synaptic plasticity; CREB1 variants may affect cognitive resilience and recovery from brain fog in Long COVID.
Can a consumer DNA test detect the rs2253206 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2253206 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for CREB1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33664986
- [2]Nature Genetics
- [3]Science