FFAR4 Gene

What is the FFAR4 gene?

FFAR4 encodes free fatty acid receptor 4, a protein involved in SCFA signaling. It belongs to the Gut Microbiome category and is part of the Gut-Brain Axis biological cluster. FFAR4 (GPR120) is activated by long-chain omega-3 fatty acids and functions as an anti-inflammatory receptor in macrophages and enteroendocrine cells, mediating insulin sensitization and appetite regulation.

Biological role and pathway

FFAR4 is involved in the SCFA signaling pathway, which plays a central role in regulating physiological processes relevant to immune defence, cellular energy, and systemic homeostasis. Genes within the Gut-Brain Axis cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function in these systems — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Known genetic variants

The following variants (SNPs) in the FFAR4 gene have been studied in relation to gut microbiome and chronic illness. Each variant represents a single nucleotide position where individuals may carry different alleles.

• rs116454156— FFAR4 variant
• rs1574941— FFAR4 variant

Conditions studied in relation to FFAR4

Research into FFAR4 variants has explored associations with the following conditions. These are areas of scientific investigation and do not imply that FFAR4 causes or treats any condition.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include FFAR4 and related genes in the gut-brain axis pathway.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Related genes in the Gut-Brain Axis pathway

FFAR4 does not act in isolation. The following genes are functionally related and may be analysed together for a more complete picture of your genetic predispositions.

Frequently asked questions