rs116454156
Variant in the FFAR4 gene (Free Fatty Acid Receptor 4)
rs116454156 is a single nucleotide polymorphism (SNP) in the FFAR4 gene, involved in SCFA signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs116454156 variant?
rs116454156 is a SNP (single nucleotide polymorphism) in the FFAR4 (Free Fatty Acid Receptor 4) gene. It belongs to the Gut Microbiome category and is part of the Gut-Brain Axis biological cluster. FFAR4 (GPR120) is activated by long-chain omega-3 fatty acids and functions as an anti-inflammatory receptor in macrophages and enteroendocrine cells, mediating insulin sensitization and appetite regulation.
Biological role and pathway
This variant sits within the FFAR4 gene, which is involved in the SCFA signaling pathway. Genes within the Gut-Brain Axis cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs116454156 and Long COVID / ME-CFS research
FFAR4 mediates the anti-inflammatory effects of omega-3 fatty acids. FFAR4 variants (notably p.R270H) are associated with obesity and insulin resistance, which are risk factors for severe COVID-19 and prolonged recovery.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: FFAR4
rs116454156 is one of 2 known variants in the FFAR4 gene. To understand the full biological context of this variant, explore the parent gene page.
View FFAR4 gene page →Conditions studied in relation to rs116454156
Research into FFAR4 variants including rs116454156 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include FFAR4 and the rs116454156 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the FFAR4 gene
The following variants in FFAR4 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs116454156 variant in the FFAR4 gene?
rs116454156 is a single nucleotide polymorphism (SNP) located in the FFAR4 (Free Fatty Acid Receptor 4) gene, which is involved in SCFA signaling. FFAR4 (GPR120) is activated by long-chain omega-3 fatty acids and functions as an anti-inflammatory receptor in macrophages and enteroendocrine cells, mediating insulin sensitization and appetite regulation.
How may the rs116454156 variant relate to Long COVID or ME/CFS?
FFAR4 mediates the anti-inflammatory effects of omega-3 fatty acids. FFAR4 variants (notably p.R270H) are associated with obesity and insulin resistance, which are risk factors for severe COVID-19 and prolonged recovery.
Can a consumer DNA test detect the rs116454156 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs116454156 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for FFAR4 and its variants. This is not an exhaustive literature review.
- [1]PMID: 24561375
- [2]Nature
- [3]Cell Metabolism