HGF Gene

What is the HGF gene?

HGF encodes hepatocyte growth factor, a protein involved in MET receptor / tissue repair. It belongs to the Signaling category and is part of the Respiratory & Lung Function biological cluster. HGF encodes hepatocyte growth factor, the primary ligand for MET receptor that drives epithelial repair and anti-fibrotic responses.

Biological role and pathway

HGF is involved in the MET receptor / tissue repair pathway, which plays a central role in regulating physiological processes relevant to immune defence, cellular energy, and systemic homeostasis. Genes within the Respiratory & Lung Function cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function in these systems — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Known genetic variants

The following variants (SNPs) in the HGF gene have been studied in relation to signaling and chronic illness. Each variant represents a single nucleotide position where individuals may carry different alleles.

• rs5745718— HGF variant
• rs1523222— HGF variant

Conditions studied in relation to HGF

Research into HGF variants has explored associations with the following conditions. These are areas of scientific investigation and do not imply that HGF causes or treats any condition.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include HGF and related genes in the respiratory & lung function pathway.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Related genes in the Respiratory & Lung Function pathway

HGF does not act in isolation. The following genes are functionally related and may be analysed together for a more complete picture of your genetic predispositions.

Frequently asked questions