rs5745718
Variant in the HGF gene (Hepatocyte Growth Factor)
rs5745718 is a single nucleotide polymorphism (SNP) in the HGF gene, involved in MET receptor / tissue repair. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs5745718 variant?
rs5745718 is a SNP (single nucleotide polymorphism) in the HGF (Hepatocyte Growth Factor) gene. It belongs to the Signaling category and is part of the Respiratory & Lung Function biological cluster. HGF encodes hepatocyte growth factor, the primary ligand for MET receptor that drives epithelial repair and anti-fibrotic responses.
Biological role and pathway
This variant sits within the HGF gene, which is involved in the MET receptor / tissue repair pathway. Genes within the Respiratory & Lung Function cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs5745718 and Long COVID / ME-CFS research
HGF has anti-fibrotic effects in the lung; variants affecting HGF levels may influence pulmonary fibrosis risk and lung function recovery in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: HGF
rs5745718 is one of 2 known variants in the HGF gene. To understand the full biological context of this variant, explore the parent gene page.
View HGF gene page →Conditions studied in relation to rs5745718
Research into HGF variants including rs5745718 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include HGF and the rs5745718 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the HGF gene
The following variants in HGF are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs5745718 variant in the HGF gene?
rs5745718 is a single nucleotide polymorphism (SNP) located in the HGF (Hepatocyte Growth Factor) gene, which is involved in MET receptor / tissue repair. HGF encodes hepatocyte growth factor, the primary ligand for MET receptor that drives epithelial repair and anti-fibrotic responses.
How may the rs5745718 variant relate to Long COVID or ME/CFS?
HGF has anti-fibrotic effects in the lung; variants affecting HGF levels may influence pulmonary fibrosis risk and lung function recovery in Long COVID.
Can a consumer DNA test detect the rs5745718 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs5745718 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for HGF and its variants. This is not an exhaustive literature review.
- [1]PMID: 33141942
- [2]Nature Genetics
- [3]Cell