HTR1A Gene

What is the HTR1A gene?

HTR1A encodes 5-hydroxytryptamine receptor 1a, a protein involved in serotonin autoreceptor / HPA axis. It belongs to the Neurotransmitter category and is part of the Neurological & Cognitive Function biological cluster. HTR1A encodes the 5-HT1A serotonin receptor, which functions as both an autoreceptor on raphe neurons and a post-synaptic receptor in limbic regions.

Biological role and pathway

HTR1A is involved in the serotonin autoreceptor / HPA axis pathway, which plays a central role in regulating physiological processes relevant to immune defence, cellular energy, and systemic homeostasis. Genes within the Neurological & Cognitive Function cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function in these systems — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Known genetic variants

The following variants (SNPs) in the HTR1A gene have been studied in relation to neurotransmitter and chronic illness. Each variant represents a single nucleotide position where individuals may carry different alleles.

• rs6295— HTR1A variant
• rs1364043— HTR1A variant

Conditions studied in relation to HTR1A

Research into HTR1A variants has explored associations with the following conditions. These are areas of scientific investigation and do not imply that HTR1A causes or treats any condition.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include HTR1A and related genes in the neurological & cognitive function pathway.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Related genes in the Neurological & Cognitive Function pathway

HTR1A does not act in isolation. The following genes are functionally related and may be analysed together for a more complete picture of your genetic predispositions.

Frequently asked questions