rs6295

What is the rs6295 variant?

rs6295 is a SNP (single nucleotide polymorphism) in the HTR1A (5-Hydroxytryptamine Receptor 1A) gene. It belongs to the Neurotransmitter category and is part of the Neurological & Cognitive Function biological cluster. HTR1A encodes the 5-HT1A serotonin receptor, which functions as both an autoreceptor on raphe neurons and a post-synaptic receptor in limbic regions.

Biological role and pathway

This variant sits within the HTR1A gene, which is involved in the serotonin autoreceptor / HPA axis pathway. Genes within the Neurological & Cognitive Function cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: HTR1A

rs6295 is one of 2 known variants in the HTR1A gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs6295

Research into HTR1A variants including rs6295 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include HTR1A and the rs6295 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the HTR1A gene

The following variants in HTR1A are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions