IL36RN Gene

What is the IL36RN gene?

IL36RN encodes interleukin 36 receptor antagonist, a protein involved in IL-36 pathway inhibition. It belongs to the Immune Signaling category and is part of the Cytokines & Immune Signaling biological cluster. IL36RN encodes the IL-36 receptor antagonist, blocking pro-inflammatory IL-36 signaling at skin and mucosal surfaces.

Biological role and pathway

IL36RN is involved in the IL-36 pathway inhibition pathway, which plays a central role in regulating physiological processes relevant to immune defence, cellular energy, and systemic homeostasis. Genes within the Cytokines & Immune Signaling cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function in these systems — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Known genetic variants

The following variants (SNPs) in the IL36RN gene have been studied in relation to immune signaling and chronic illness. Each variant represents a single nucleotide position where individuals may carry different alleles.

• rs2271069— IL36RN variant

Conditions studied in relation to IL36RN

Research into IL36RN variants has explored associations with the following conditions. These are areas of scientific investigation and do not imply that IL36RN causes or treats any condition.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include IL36RN and related genes in the cytokines & immune signaling pathway.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Related genes in the Cytokines & Immune Signaling pathway

IL36RN does not act in isolation. The following genes are functionally related and may be analysed together for a more complete picture of your genetic predispositions.

Frequently asked questions