rs2271069

What is the rs2271069 variant?

rs2271069 is a SNP (single nucleotide polymorphism) in the IL36RN (Interleukin 36 Receptor Antagonist) gene. It belongs to the Immune Signaling category and is part of the Cytokines & Immune Signaling biological cluster. IL36RN encodes the IL-36 receptor antagonist, blocking pro-inflammatory IL-36 signaling at skin and mucosal surfaces.

Biological role and pathway

This variant sits within the IL36RN gene, which is involved in the IL-36 pathway inhibition pathway. Genes within the Cytokines & Immune Signaling cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: IL36RN

rs2271069 is one of 1 known variant in the IL36RN gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs2271069

Research into IL36RN variants including rs2271069 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include IL36RN and the rs2271069 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions