ISG15 Gene

What is the ISG15 gene?

ISG15 encodes isg15 ubiquitin like modifier, a protein involved in ISGylation antiviral defense. It belongs to the Antiviral category and is part of the Viral Defense & Interferon Response biological cluster. ISG15 encodes an interferon-stimulated ubiquitin-like modifier that conjugates to viral and host proteins, restricting viral replication.

Biological role and pathway

ISG15 is involved in the ISGylation antiviral defense pathway, which plays a central role in regulating physiological processes relevant to immune defence, cellular energy, and systemic homeostasis. Genes within the Viral Defense & Interferon Response cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function in these systems — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Known genetic variants

The following variants (SNPs) in the ISG15 gene have been studied in relation to antiviral and chronic illness. Each variant represents a single nucleotide position where individuals may carry different alleles.

• rs1549596— ISG15 variant

Conditions studied in relation to ISG15

Research into ISG15 variants has explored associations with the following conditions. These are areas of scientific investigation and do not imply that ISG15 causes or treats any condition.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include ISG15 and related genes in the viral defense & interferon response pathway.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Related genes in the Viral Defense & Interferon Response pathway

ISG15 does not act in isolation. The following genes are functionally related and may be analysed together for a more complete picture of your genetic predispositions.

Frequently asked questions