LCT Gene

What is the LCT gene?

LCT encodes lactase, a protein involved in intestinal carbohydrate metabolism. It belongs to the Gut Microbiome category and is part of the Gut & Microbiome Interaction biological cluster. LCT encodes lactase, the intestinal enzyme that cleaves lactose; the LCT-13910C>T polymorphism determines lactase persistence in adulthood.

Biological role and pathway

LCT is involved in the intestinal carbohydrate metabolism pathway, which plays a central role in regulating physiological processes relevant to immune defence, cellular energy, and systemic homeostasis. Genes within the Gut & Microbiome Interaction cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function in these systems — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Known genetic variants

The following variants (SNPs) in the LCT gene have been studied in relation to gut microbiome and chronic illness. Each variant represents a single nucleotide position where individuals may carry different alleles.

• rs4988235— LCT variant
• rs182549— LCT variant

Conditions studied in relation to LCT

Research into LCT variants has explored associations with the following conditions. These are areas of scientific investigation and do not imply that LCT causes or treats any condition.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include LCT and related genes in the gut & microbiome interaction pathway.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Related genes in the Gut & Microbiome Interaction pathway

LCT does not act in isolation. The following genes are functionally related and may be analysed together for a more complete picture of your genetic predispositions.

Frequently asked questions