FUT2 Gene

What is the FUT2 gene?

FUT2 encodes fucosyltransferase 2, a protein involved in gut mucosal immunity. It belongs to the Gut Microbiome category and is part of the Gut & Microbiome Interaction biological cluster. FUT2 encodes fucosyltransferase 2, which determines ABO blood group secretor status and influences gut microbiome composition.

Biological role and pathway

FUT2 is involved in the gut mucosal immunity pathway, which plays a central role in regulating physiological processes relevant to immune defence, cellular energy, and systemic homeostasis. Genes within the Gut & Microbiome Interaction cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function in these systems — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Known genetic variants

The following variants (SNPs) in the FUT2 gene have been studied in relation to gut microbiome and chronic illness. Each variant represents a single nucleotide position where individuals may carry different alleles.

• rs601338— FUT2 variant
• rs1047781— FUT2 variant

Conditions studied in relation to FUT2

Research into FUT2 variants has explored associations with the following conditions. These are areas of scientific investigation and do not imply that FUT2 causes or treats any condition.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include FUT2 and related genes in the gut & microbiome interaction pathway.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Related genes in the Gut & Microbiome Interaction pathway

FUT2 does not act in isolation. The following genes are functionally related and may be analysed together for a more complete picture of your genetic predispositions.

Frequently asked questions