MAT1A Gene
Methionine Adenosyltransferase 1A (MAT1A) is a gene involved in SAM biosynthesis that has been studied in relation to immune function, metabolism, and chronic illness. Variants in MAT1A may influence how the body responds to infection, inflammation, and long-term recovery.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the MAT1A gene?
MAT1A encodes methionine adenosyltransferase 1a, a protein involved in SAM biosynthesis. It belongs to the Methylation category and is part of the Methylation & Neurotransmitters biological cluster. MAT1A encodes the liver-specific isoform of methionine adenosyltransferase, which synthesizes S-adenosylmethionine (SAM) from methionine.
Biological role and pathway
MAT1A is involved in the SAM biosynthesis pathway, which plays a central role in regulating physiological processes relevant to immune defence, cellular energy, and systemic homeostasis. Genes within the Methylation & Neurotransmitters cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function in these systems — particularly under conditions of physiological stress such as viral infection or prolonged illness.
MAT1A and Long COVID / ME-CFS research
MAT1A function is essential for maintaining SAM levels, the universal methyl donor; variants may limit methylation capacity in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Known genetic variants
The following variants (SNPs) in the MAT1A gene have been studied in relation to methylation and chronic illness. Each variant represents a single nucleotide position where individuals may carry different alleles.
- rs1805083— MAT1A variant
Conditions studied in relation to MAT1A
Research into MAT1A variants has explored associations with the following conditions. These are areas of scientific investigation and do not imply that MAT1A causes or treats any condition.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include MAT1A and related genes in the methylation & neurotransmitters pathway.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Related genes in the Methylation & Neurotransmitters pathway
MAT1A does not act in isolation. The following genes are functionally related and may be analysed together for a more complete picture of your genetic predispositions.
Frequently asked questions
What is the MAT1A gene and what does it do?
MAT1A (Methionine Adenosyltransferase 1A) is involved in SAM biosynthesis. MAT1A encodes the liver-specific isoform of methionine adenosyltransferase, which synthesizes S-adenosylmethionine (SAM) from methionine.
How may MAT1A gene variants relate to Long COVID or ME/CFS?
MAT1A function is essential for maintaining SAM levels, the universal methyl donor; variants may limit methylation capacity in Long COVID.
Can a DNA test reveal information about my MAT1A gene?
Consumer DNA data from 23andMe, AncestryDNA, and MyHeritage includes SNP variants for many genes. ChronicDNA analyses your raw DNA file and reports on variants that have been studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Explore your MAT1A genetic insights
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for MAT1A. This is not an exhaustive literature review.
- [1]PMID: 9694677
- [2]Nature Genetics
- [3]Journal of Clinical Investigation