rs1805083

What is the rs1805083 variant?

rs1805083 is a SNP (single nucleotide polymorphism) in the MAT1A (Methionine Adenosyltransferase 1A) gene. It belongs to the Methylation category and is part of the Methylation & Neurotransmitters biological cluster. MAT1A encodes the liver-specific isoform of methionine adenosyltransferase, which synthesizes S-adenosylmethionine (SAM) from methionine.

Biological role and pathway

This variant sits within the MAT1A gene, which is involved in the SAM biosynthesis pathway. Genes within the Methylation & Neurotransmitters cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: MAT1A

rs1805083 is one of 1 known variant in the MAT1A gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs1805083

Research into MAT1A variants including rs1805083 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include MAT1A and the rs1805083 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions